Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.36 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.36 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4771123 | 1.00 | MAPT (0.40) | MAPTMITFALDH1A1GAAHPGD | |
| SCHEMBL4768028 | 0.93 | MAPK1 (0.39) | MAPTMITFALDH1A1GAAHPGD | |
| SCHEMBL4768016 | 0.93 | MAPK1 (0.39) | MAPTMITFALDH1A1GAAHPGD | |
| SCHEMBL4762619 | 0.88 | SMN1; SMN2 (0.41) | MAPTMITFALDH1A1GAAHPGD | |
| SCHEMBL4762614 | 0.88 | SMN1; SMN2 (0.41) | MAPTMITFALDH1A1GAAHPGD | |
| SCHEMBL4771507 | 0.87 | MAPT (0.36) | MAPTMITFALDH1A1GAAHPGD | |
| SCHEMBL4763390 | 0.83 | NCOA1 (0.44) | MAPTMITFALDH1A1SMN1; SMN2POLB | |
| SCHEMBL4763392 | 0.83 | NCOA1 (0.44) | MAPTMITFALDH1A1SMN1; SMN2POLB | |
| SCHEMBL4765722 | 0.83 | TP53 (0.41) | MAPTALDH1A1GAALMNAMEN1 | |
| SCHEMBL4793254 | 0.83 | NPC1 (0.36) | MAPTMITFALDH1A1GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678181-B1 | A2B ADENOSINE RECEPTOR ANTAGONISTS | CV THERAPEUTICS INC (US) | 2008-12-31 | — | — | EP | disclosed |