Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 7/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | PARG | Q86W56 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4768028 | 1.00 | MAPK1 (0.39) | MAPK1LMNANPSR1MAPTADORA2A | |
| SCHEMBL4771148 | 0.93 | MAPT (0.40) | MAPK1LMNAMAPTADORA2BADORA3 | |
| SCHEMBL4771123 | 0.93 | MAPT (0.40) | MAPK1LMNAMAPTADORA2BADORA3 | |
| SCHEMBL4793245 | 0.91 | NPC1 (0.36) | MAPK1LMNANPSR1MAPTADORA2A | |
| SCHEMBL4793254 | 0.91 | NPC1 (0.36) | MAPK1LMNANPSR1MAPTADORA2A | |
| SCHEMBL4766101 | 0.90 | MAPT (0.39) | MAPK1LMNANPSR1MAPTADORA2A | |
| SCHEMBL4766095 | 0.90 | MAPT (0.39) | MAPK1LMNANPSR1MAPTADORA2A | |
| SCHEMBL4771549 | 0.85 | ADORA2B (0.38) | MAPK1LMNANPSR1MAPTADORA2A | |
| SCHEMBL4771531 | 0.85 | ADORA2B (0.38) | MAPK1LMNANPSR1MAPTADORA2A | |
| SCHEMBL4764008 | 0.84 | ADORA2B (0.41) | MAPK1LMNANPSR1MAPTADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678181-B1 | A2B ADENOSINE RECEPTOR ANTAGONISTS | CV THERAPEUTICS INC (US) | 2008-12-31 | — | — | EP | disclosed |