Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 3/20 | 0.37 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.36 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4769324 | 0.81 | C5AR1 (0.39) | C5AR1BCHEPTGDRCXCR3GSK3B | |
| SCHEMBL649270 | 0.79 | ACHE (0.36) | C5AR1MEN1KMT2ABCHESMN1; SMN2 | |
| SCHEMBL4769327 | 0.78 | C5AR1 (0.44) | C5AR1BCHECXCR3GSK3BGNRHR | |
| SCHEMBL5136874 | 0.73 | C5AR1 (0.54) | C5AR1CXCR3CHRM5CHRM1 | |
| SCHEMBL5134570 | 0.72 | C5AR1 (0.54) | C5AR1BCHECXCR3ALDH1A1MAPT | |
| SCHEMBL653131 | 0.72 | C5AR1 (0.59) | C5AR1CXCR3SMN1; SMN2CHRM5CHRM1 | |
| SCHEMBL649152 | 0.71 | C5AR1 (0.47) | C5AR1CXCR3CHRM5CHRM1GNRHR | |
| SCHEMBL5135332 | 0.71 | C5AR1 (0.59) | C5AR1MEN1KMT2ABCHERAB9A | |
| SCHEMBL5135904 | 0.71 | C5AR1 (0.56) | C5AR1MEN1KMT2ABCHERAB9A | |
| SCHEMBL1915326 | 0.70 | C5AR1 (0.51) | C5AR1CXCR3RAB9ANPC1CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322309-B1 | HIGH AFFINITY SMALL MOLECULE C5A RECEPTOR MODULATORS | NEUROGEN CORP (US) | 2008-08-13 | — | — | EP | claimed |