Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESRRA | P11474 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.39 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4771748 | 0.78 | MARS1 (0.46) | ESRRAPTGS1PTGS2MAPTRAD51 | |
| SCHEMBL12325069 | 0.73 | HSP90AA1 (0.56) | MAPTRAB9AKMT2AMEN1HPGD | |
| SCHEMBL4778866 | 0.73 | CHRNA7 (0.42) | PTGS1PTGS2KMT2AMEN1TP53 | |
| SCHEMBL4778476 | 0.68 | TP53 (0.43) | PTGS1PTGS2KMT2AMEN1TP53 | |
| SCHEMBL7906452 | 0.67 | HSP90AA1 (0.50) | MAPTRAB9AKMT2AMEN1HPGD | |
| SCHEMBL4779727 | 0.66 | TP53 (0.41) | MAPTRAB9AKMT2AMEN1TP53 | |
| SCHEMBL5478017 | 0.66 | HSP90AA1 (0.43) | MAPTRAB9AKMT2AMEN1HPGD | |
| SCHEMBL28303202 | 0.65 | ESR2 (0.57) | MAPTRAB9AKMT2AMEN1TP53 | |
| SCHEMBL9732916 | 0.65 | CYP2A6 (0.50) | MAPTRAB9AKMT2AMEN1TP53 | |
| SCHEMBL14055298 | 0.65 | HSP90AA1 (0.55) | MAPTRAB9AKMT2AMEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1889617-A1 | Triphenyl modified 5-membered heterocycles and their use as anticancer and antiflammatory agents | Freie Universität Berlin (DE) | 2008-02-20 | — | — | EP | claimed |
| WO-2008006626-A1 | TRIPHENYL MODIFIED 5-MEMBERED HETEROCYCLES AND THEIR USE AS ANTICANCER AND ANTIINFLAMMATORY AGENTS | FREIE UNIVERSITÄT BERLIN (DE) | 2008-01-17 | — | — | WO | claimed |
| EP-1889617-A1 | Triphenyl modified 5-membered heterocycles and their use as anticancer and antiflammatory agents | Freie Universität Berlin (DE) | 2008-02-20 | — | — | EP | disclosed |