Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TSPO | P30536 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | CES2 | O00748 | 1/20 | 0.30 |
| ▸ | CES1 | P23141 | 1/20 | 0.30 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1939814 | 0.85 | GAA (0.46) | GAASMN1; SMN2ALDH1A1TP53MAPT | |
| SCHEMBL11083920 | 0.76 | GAA (0.39) | GAASMN1; SMN2ALDH1A1TP53MAPT | |
| SCHEMBL15513489 | 0.74 | GAA (0.38) | GAASMN1; SMN2ALDH1A1TP53MAPT | |
| SCHEMBL9360259 | 0.74 | ALDH1A1 (0.48) | GAASMN1; SMN2ALDH1A1TP53MAPT | |
| SCHEMBL7114177 | 0.74 | HSD17B10 (0.44) | ALDH1A1MAPTTSHRKMT2AMEN1 | |
| SCHEMBL5167275 | 0.70 | NPSR1 (0.46) | SMN1; SMN2ALDH1A1TP53TSHRKMT2A | |
| SCHEMBL7388059 | 0.68 | ALDH1A1 (0.39) | GAASMN1; SMN2ALDH1A1TP53MAPT | |
| SCHEMBL28875374 | 0.67 | MAPT (0.37) | GAASMN1; SMN2ALDH1A1TP53MAPT | |
| SCHEMBL10771938 | 0.66 | TSHR (0.32) | TSHR | |
| SCHEMBL21513960 | 0.66 | GAA (0.70) | GAASMN1; SMN2ALDH1A1TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1729795-A4 | ALBUMIN FUSION PROTEINS | HUMAN GENOME SCIENCES INC (US) | 2008-05-21 | — | — | EP | disclosed |
| EP-1729795-A2 | ALBUMIN FUSION PROTEINS | Human Genome Sciences, Inc. (US) | 2006-12-13 | — | — | EP | disclosed |
| WO-2005077042-A2 | ALBUMIN FUSION PROTEINS | HUMAN GENOME SCIENCES, INC. (US) | 2005-08-25 | — | — | WO | disclosed |