Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 5/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4029041 | 0.90 | KDM4E (0.38) | OPRM1OPRD1OPRK1KDRALDH1A1 | |
| SCHEMBL4780110 | 0.89 | OPRM1 (0.33) | OPRM1OPRD1OPRK1KDM2BMEN1 | |
| SCHEMBL4027439 | 0.89 | OPRM1 (0.35) | OPRM1OPRD1OPRK1ALDH1A1DRD2 | |
| SCHEMBL4027446 | 0.89 | OPRM1 (0.35) | OPRM1OPRD1OPRK1ALDH1A1DRD2 | |
| SCHEMBL4779051 | 0.88 | KDM4E (0.36) | OPRM1OPRD1OPRK1KDRALDH1A1 | |
| SCHEMBL4024525 | 0.87 | MEN1 (0.35) | OPRM1OPRD1OPRK1ALDH1A1KDM2B | |
| SCHEMBL13720775 | 0.87 | MEN1 (0.35) | OPRM1OPRD1OPRK1ALDH1A1KDM2B | |
| SCHEMBL4024540 | 0.87 | MEN1 (0.35) | OPRM1OPRD1OPRK1ALDH1A1KDM2B | |
| SCHEMBL4020633 | 0.87 | MEN1 (0.35) | OPRM1OPRD1OPRK1KDM2BMEN1 | |
| SCHEMBL4028045 | 0.87 | OPRM1 (0.35) | OPRM1OPRD1OPRK1KCNH2KDM2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1962846-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007059323-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-24 | — | — | WO | disclosed |