Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | CDK2 | P24941 | 4/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.44 |
| ▸ | CDK9 | P50750 | 2/20 | 0.44 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.44 |
| ▸ | CDK1 | P06493 | 5/20 | 0.43 |
| ▸ | KDR | P35968 | 5/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.42 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 3/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4763589 | 0.87 | AURKA (0.51) | CA2AURKACDK2CCNT1CCNA2 | |
| SCHEMBL4768143 | 0.87 | SYK (0.53) | CA2AURKACDK2CCNT1CCNA2 | |
| SCHEMBL4772198 | 0.87 | AURKA (0.46) | CA2AURKACDK2CCNT1CCNA2 | |
| SCHEMBL4766554 | 0.87 | AURKA (0.46) | CA2AURKACDK2CCNT1CCNA2 | |
| SCHEMBL4766260 | 0.85 | SYK (0.55) | AURKACDK2CCNT1CCNA2CDK9 | |
| SCHEMBL4772264 | 0.85 | AURKA (0.47) | CA2AURKACDK2CCNT1CCNA2 | |
| SCHEMBL4774317 | 0.85 | AURKA (0.53) | CA2AURKACDK2CCNT1CCNA2 | |
| SCHEMBL4768983 | 0.85 | AURKA (0.53) | CA2AURKACDK2CCNT1CCNA2 | |
| SCHEMBL4763519 | 0.84 | AURKA (0.47) | CA2AURKACDK2CCNT1CCNA2 | |
| SCHEMBL4773980 | 0.84 | AURKA (0.52) | CA2AURKACDK2CCNT1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303496-B9 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| EP-1303496-B1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-12 | — | — | EP | disclosed |
| US-6908920-B2 | Pyrimidine derivatives | ASTRAZENECA AB (SE) | 2005-06-21 | — | — | US | disclosed |