Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 15/20 | 0.43 |
| ▸ | CDK2 | P24941 | 14/20 | 0.43 |
| ▸ | KDR | P35968 | 13/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.43 |
| ▸ | CDK9 | P50750 | 3/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | CDK4 | P11802 | 2/20 | 0.41 |
| ▸ | CDK7 | P50613 | 2/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.41 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CCNH | P51946 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4763519 | 0.91 | AURKA (0.47) | AURKACDK1CDK2KDRCCNB1 | |
| SCHEMBL4768143 | 0.86 | SYK (0.53) | AURKACDK1CDK2KDRCCNB1 | |
| SCHEMBL4772099 | 0.85 | CA2 (0.52) | AURKACDK1CDK2KDRCCNB1 | |
| SCHEMBL4763589 | 0.84 | AURKA (0.51) | AURKACDK1CDK2KDRCCNB1 | |
| SCHEMBL6496016 | 0.84 | SLC6A9 (0.41) | AURKACDK1CDK2KDRCCNE1 | |
| SCHEMBL4766554 | 0.84 | AURKA (0.46) | AURKACDK1CDK2KDRCDK9 | |
| SCHEMBL4772198 | 0.84 | AURKA (0.46) | AURKACDK1CDK2KDRCCNB1 | |
| SCHEMBL4770519 | 0.83 | AURKA (0.46) | AURKACDK1CDK2KDRCCNB1 | |
| SCHEMBL4766260 | 0.82 | SYK (0.55) | AURKACDK1CDK2CCNB1CDK9 | |
| SCHEMBL4774317 | 0.82 | AURKA (0.53) | AURKACDK1CDK2KDRCDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303496-B9 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| EP-1303496-B1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-12 | — | — | EP | disclosed |