Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4773735 | 0.95 | ALOX5 (0.40) | GRIK1ALOX5HDAC1SMN1; SMN2HDAC3 | |
| SCHEMBL7151687 | 0.85 | HDAC3 (0.47) | GRIK1HDAC1SMN1; SMN2HDAC3HDAC4 | |
| SCHEMBL4558971 | 0.81 | SMN1; SMN2 (0.47) | HDAC1SMN1; SMN2HDAC3HDAC4HDAC7 | |
| SCHEMBL1952933 | 0.77 | ALOX5 (0.56) | ALOX5HDAC1SMN1; SMN2HDAC3HDAC4 | |
| SCHEMBL4561028 | 0.76 | SMN1; SMN2 (0.49) | HDAC1SMN1; SMN2HDAC3HDAC4HDAC7 | |
| SCHEMBL1954648 | 0.75 | SIGMAR1 (0.53) | ALOX5HDAC1SMN1; SMN2HDAC3HDAC4 | |
| SCHEMBL12329847 | 0.75 | HRH1 (0.44) | ALOX5SMN1; SMN2MAPK1SLC6A3CYP1A2 | |
| SCHEMBL1955414 | 0.74 | SIGMAR1 (0.56) | ALOX5HDAC1SMN1; SMN2HDAC3HDAC4 | |
| SCHEMBL16933744 | 0.74 | SIGMAR1 (0.56) | ALOX5HDAC1SMN1; SMN2HDAC3HDAC4 | |
| SCHEMBL1954943 | 0.74 | SIGMAR1 (0.56) | ALOX5HDAC1SMN1; SMN2HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874283-A2 | USE OF NOVEL COMPOUNDS FOR IBD TREATMENT | Ferring BV (NL) | 2008-01-09 | — | — | EP | claimed |
| WO-2006116399-A2 | USE OF NOVEL COMPOUNDS FOR IBD TREATMENT | FERRING B.V. (NL) | 2006-11-02 | — | — | WO | claimed |
| EP-1675822-A2 | AMIDE OR THIOAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PAIN | Cara Therapeutics, Inc. (US) | 2006-07-05 | — | — | EP | claimed |
| WO-2005037798-A2 | AMIDE OR THIOMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PAIN | CARA THERAPEUTICS, INC (US) | 2005-04-28 | — | — | WO | claimed |
| EP-1675822-A2 | AMIDE OR THIOAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PAIN | Cara Therapeutics, Inc. (US) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005037798-A2 | AMIDE OR THIOMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PAIN | CARA THERAPEUTICS, INC (US) | 2005-04-28 | — | — | WO | disclosed |