Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | GAA | P10253 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | STK17B | O94768 | 1/20 | 0.39 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.39 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27502303 | 0.91 | CSNK1A1 (0.51) | CSNK1A1CLK4ALDH1A1KDM4EGAA | |
| SCHEMBL4768640 | 0.85 | POLB (0.49) | CSNK1A1CLK4ALDH1A1KDM4EGAA | |
| SCHEMBL4772159 | 0.82 | CSNK1A1 (0.47) | CSNK1A1CLK4ALDH1A1GAACCNA2 | |
| SCHEMBL4770462 | 0.80 | ALDH1A1 (0.47) | CSNK1A1CLK4ALDH1A1KDM4EGAA | |
| SCHEMBL4766397 | 0.80 | CSNK1A1 (0.51) | CSNK1A1CLK4ALDH1A1KDM4EGAA | |
| SCHEMBL1400319 | 0.80 | STK17A (0.56) | LMNASTK17BSTK17AKMT2ACYP1A2 | |
| SCHEMBL4765894 | 0.78 | CSNK1A1 (0.50) | CSNK1A1CLK4ALDH1A1KDM4EGAA | |
| SCHEMBL4579364 | 0.78 | SMN1; SMN2 (0.45) | CSNK1A1CLK4ALDH1A1KDM4EGAA | |
| SCHEMBL4765379 | 0.78 | CSNK1A1 (0.44) | CSNK1A1CLK4ALDH1A1KDM4EGAA | |
| SCHEMBL2821095 | 0.77 | STK17B (0.41) | ALDH1A1LMNASTK17BSTK17ASIRT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12435063-B2 | Nitrogen containing heterocycles as CDK12 inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2025-10-07 | — | — | US | disclosed |
| EP-3782986-B1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICALS CO (JP) | 2024-07-10 | — | — | EP | disclosed |
| CN-111918863-B | Heterocyclic compounds | 武田药品工业株式会社 | 2024-01-05 | — | — | CN | disclosed |
| US-20230117295-A1 | NITROGEN CONTAINING HETEROCYCLES AS CDK12 INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2023-04-20 | — | — | US | disclosed |
| US-11584737-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2023-02-21 | — | — | US | disclosed |
| US-20210363130-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2021-11-25 | — | — | US | disclosed |
| EP-3782986-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2021-02-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230117295-A1 | NITROGEN CONTAINING HETEROCYCLES AS CDK12 INHIBITORS | CDK1, CDK12, CDK15 | CSNK1A1 245/4885CLK4 500/4885ALDH1A1 4719/4885 |
| US-11584737-B2 | Heterocyclic compound | CDK12, CDK1, CDK15 | CSNK1A1 221/4885CLK4 487/4885ALDH1A1 4524/4885 |
| US-20210363130-A1 | HETEROCYCLIC COMPOUND | CDK12, CDK1, CDK15 | CSNK1A1 221/4885CLK4 487/4885ALDH1A1 4524/4885 |
| US-12435063-B2 | Nitrogen containing heterocycles as CDK12 inhibitors | CDK1, CDK12, CDK15 | CSNK1A1 245/4885CLK4 500/4885ALDH1A1 4719/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.