SCHEMBL4772315

SCHEMBL4772315

COc1ccc(C(OC[C@@]23CCO[C@@H]([C@H](n4ccc(=O)[nH]c4=O)O2)[C@@H]3OP(OCCC#N)N(C(C)C)C(C)C)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1408601 0.94
SCHEMBL4087414 0.94
SCHEMBL26869 0.91 TK2 (0.33)
SCHEMBL9104276 0.88
SCHEMBL17255162 0.87 P2RY14 (0.30)
SCHEMBL7093044 0.87 DUT (0.30)
SCHEMBL12386211 0.87 DUT (0.30)
SCHEMBL1526489 0.86 DUT (0.30)
SCHEMBL6441180 0.86 P2RY6 (0.33)
SCHEMBL1666162 0.85 P2RY14 (0.30)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1152009-B2 NOVEL NUCLEOSIDES AND OLIGONUCLEOTIDE ANALOGUES DAIICHI SANKYO CO LTD (JP) 2017-09-06 EP claimed
US-7335765-B2 Nucleoside and oligonucleotide analogues DAIICHI SANKYO COMPANY, LIMITED (JP) 2008-02-26 US claimed
EP-1152009-B1 NOVEL NUCLEOSIDES AND OLIGONUCLEOTIDE ANALOGUES SANKYO CO (JP) 2005-01-26 EP claimed
US-20030207841-A1 Novel nucleoside and oligonucleotide analogues SANKYO COMPANY LIMITED (JP) 2003-11-06 US claimed
US-20020147332-A1 Novel nucleoside and oligonucleotide analogues SANKYO COMPANY, LIMITED (JP) 2002-10-10 US claimed
EP-1152009-B2 NOVEL NUCLEOSIDES AND OLIGONUCLEOTIDE ANALOGUES DAIICHI SANKYO CO LTD (JP) 2017-09-06 EP disclosed
EP-1152009-B1 NOVEL NUCLEOSIDES AND OLIGONUCLEOTIDE ANALOGUES SANKYO CO (JP) 2005-01-26 EP disclosed