Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 20/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 17/20 | 0.59 |
| ▸ | DRD2 | P14416 | 16/20 | 0.59 |
| ▸ | HRH1 | P35367 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4773455 | 0.91 | DRD3 (0.67) | DRD3KCNH2DRD2 | |
| SCHEMBL4769845 | 0.91 | DRD3 (0.65) | DRD3KCNH2DRD2 | |
| SCHEMBL4839391 | 0.91 | DRD3 (0.63) | DRD3KCNH2DRD2HRH1HTR1A | |
| SCHEMBL4767832 | 0.91 | DRD3 (0.68) | DRD3KCNH2DRD2HRH1 | |
| SCHEMBL4769841 | 0.91 | DRD3 (0.66) | DRD3KCNH2DRD2 | |
| SCHEMBL4767819 | 0.90 | DRD3 (0.64) | DRD3KCNH2DRD2HRH1 | |
| SCHEMBL4770366 | 0.90 | DRD3 (0.57) | DRD3KCNH2DRD2HRH1 | |
| SCHEMBL4770291 | 0.88 | DRD3 (0.57) | DRD3KCNH2DRD2HRH1HTR1A | |
| SCHEMBL4836950 | 0.87 | DRD3 (0.53) | DRD3KCNH2DRD2HRH1 | |
| SCHEMBL5104402 | 0.85 | ALDH1A1 (0.44) | DRD3KCNH2DRD2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429579-B2 | Tetrahydrobenzazepine derivatives useful as modulators of dopamine D3 receptors (antipsychotic agents) | SMITHKLINE BEECHAM, PLC (GB) | 2008-09-30 | — | — | US | disclosed |
| EP-1335915-B1 | TETRAHYDROBENZAZEPINE DERIVATIVES USEFUL AS MODULATORS OF DOPAMINE D3 RECEPTORS (ANTIPSYCHOTIC AGENTS) | SMITHKLINE BEECHAM PLC (GB) | 2008-01-02 | — | — | EP | disclosed |
| US-20040171606-A1 | Tetrahydrobenzazepine derivatives useful as modulators of dopamine d3 receptors (antipsychotic agents) | SMITHKLINE BEECHAM PLC (GB) | 2004-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040171606-A1 | Tetrahydrobenzazepine derivatives useful as modulators of dopamine d3 receptors (antipsychotic agents) | DRD3, DRD2, DRD1 | DRD3 1/4885KCNH2 272/4885DRD2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.