SCHEMBL4772467

SCHEMBL4772467

CCn1cnc2c(=O)nc(Cc3ccc(Cl)cc3F)n(-c3ccc(F)cc3)c21

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAT2A P31153 1/20 0.40
KMT2A Q03164 3/20 0.37
ALDH1A1 P00352 2/20 0.37
TSHR P16473 2/20 0.37
POLB P06746 1/20 0.37
KCNH2 Q12809 1/20 0.35
RXFP1 Q9HBX9 1/20 0.35
P2RX7 Q99572 1/20 0.35
MAOB P27338 1/20 0.35
ADORA2A P29274 1/20 0.35
TRPA1 O75762 1/20 0.35
BRD9 Q9H8M2 1/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
MEN1 O00255 1/20 0.34
PKM P14618 1/20 0.34
CNR1 P21554 2/20 0.34
AOC3 Q16853 1/20 0.33
NPC1 O15118 1/20 0.33
LMNA P02545 1/20 0.33
HPGD P15428 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4768907 0.89 SMN1; SMN2 (0.34) MAT2AKMT2AALDH1A1TSHRRXFP1
SCHEMBL4507591 0.86 MAT2A (0.43) MAT2AKMT2AALDH1A1TSHRPOLB
SCHEMBL4778102 0.85 MAPK1 (0.36) KMT2AALDH1A1TSHRSMN1; SMN2MEN1
SCHEMBL4776782 0.83 CDK1 (0.33) MAT2ATSHRRXFP1BRD9SMN1; SMN2
SCHEMBL4777997 0.82 TSHR (0.39) KMT2AALDH1A1TSHRPOLBKCNH2
SCHEMBL4521476 0.80 GSR (0.39) MAT2ATSHRPOLBBRD9SMN1; SMN2
SCHEMBL4357095 0.79 MAT2A (0.38) MAT2AKMT2AALDH1A1TSHRPOLB
SCHEMBL4521828 0.79 MAT2A (0.40) MAT2AKMT2AALDH1A1TSHRPOLB
SCHEMBL4530159 0.78 MAT2A (0.43) MAT2AKMT2AALDH1A1TSHRRXFP1
SCHEMBL4776024 0.78 POLB (0.38) KMT2AALDH1A1TSHRPOLBKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1881988-A1 2,3-SUBSTITUTED FUSED BICYCLIC PYRIMIDIN-4(3H)-ONES MODULATING THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1) MERCK SHARP & DOHME LTD. (GB) 2008-01-30 EP disclosed
WO-2006122200-A1 2,3-SUBSTITUTED FUSED BICYCLIC PYRIMIDIN-4(3H)-ONES MODULATING THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1) MERCK SHARP & DOHME LIMITED (GB) 2006-11-16 WO disclosed