SCHEMBL4772626

SCHEMBL4772626

CCn1ncc2c(-c3ccc(F)cc3)c(C=O)c(C(C)C)nc21

nearest known ligand 0.43

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GCGR P47871 15/20 0.43
GGPS1 O95749 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4769868 0.81 CLK1 (0.36)
SCHEMBL4770236 0.81 GCGR (0.59) GCGR
SCHEMBL4778740 0.81 SIGMAR1 (0.33)
SCHEMBL4777655 0.80 ADORA3 (0.33)
SCHEMBL4769971 0.80 ADORA3 (0.34)
SCHEMBL4778882 0.80 PDE10A (0.30)
SCHEMBL9377313 0.79 HMGCR (0.62)
SCHEMBL4774010 0.78 SIGMAR1 (0.33)
SCHEMBL8949603 0.76 GCGR (0.58) GCGR
SCHEMBL4772747 0.75 CYP11B1 (0.36) GGPS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1763528-B1 PYRAZOLOPYRIDINE DERIVATIVES ASTELLAS PHARMA INC (JP) 2008-11-26 EP claimed
EP-1763528-B1 PYRAZOLOPYRIDINE DERIVATIVES ASTELLAS PHARMA INC (JP) 2008-11-26 EP disclosed