Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 7/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | CCR6 | P51684 | 1/20 | 0.33 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.33 |
| ▸ | CBFB | Q13951 | 1/20 | 0.33 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4777706 | 0.81 | NPC1 (0.43) | MAPTLMNATP53NPC1RAB9A | |
| SCHEMBL4779946 | 0.81 | NPC1 (0.35) | MAPTLMNATP53NPC1RAB9A | |
| SCHEMBL21381326 | 0.70 | SMN1; SMN2 (0.57) | MAPTLMNAMAPK1SMN1; SMN2POLB | |
| SCHEMBL3777793 | 0.67 | HPGD (0.39) | MAPTSMN1; SMN2GAAP2RX3KDM4E | |
| SCHEMBL21129084 | 0.67 | CYP1A2 (0.56) | KLK7 | |
| SCHEMBL25997018 | 0.67 | CYP1A2 (0.56) | KLK7 | |
| SCHEMBL28257746 | 0.66 | TSHR (0.55) | MAPTLMNATP53NPC1RAB9A | |
| SCHEMBL4667788 | 0.66 | PPARA (0.39) | MAPTLMNATP53NPC1RAB9A | |
| SCHEMBL14121874 | 0.66 | CYP4F2 (0.49) | LMNANPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL14121873 | 0.66 | CYP4F2 (0.49) | LMNANPC1RAB9ASMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928457-A2 | QUINOLINES AND THEIR THERAPEUTIC USE | Argenta Discovery Limited (GB) | 2008-06-11 | — | — | EP | disclosed |
| WO-2007036743-A2 | QUINOLINES AND THEIR THERAPEUTIC USE | ARGENTA DISCOVERY LIMITED (GB) | 2007-04-05 | — | — | WO | disclosed |