Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | P2RX3 | P56373 | 13/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | PPARA | Q07869 | 2/20 | 0.36 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4772679 | 0.81 | MAPT (0.47) | NPC1LMNATP53MAPTRAB9A | |
| SCHEMBL534117 | 0.80 | P2RX3 (0.40) | P2RX3 | |
| SCHEMBL534116 | 0.80 | P2RX3 (0.40) | P2RX3 | |
| SCHEMBL4779946 | 0.79 | NPC1 (0.35) | NPC1LMNATP53MAPTRAB9A | |
| SCHEMBL3777364 | 0.71 | SMN1; SMN2 (0.39) | LMNAMAPT | |
| SCHEMBL3777368 | 0.71 | SMN1; SMN2 (0.39) | LMNAMAPT | |
| SCHEMBL3777793 | 0.70 | HPGD (0.39) | MAPTP2RX3 | |
| SCHEMBL11319078 | 0.69 | EPHX2 (0.54) | MAPTPPARGPPARA | |
| SCHEMBL3773014 | 0.69 | KDM4E (0.40) | LMNAMAPT | |
| SCHEMBL3772179 | 0.69 | KDM4E (0.40) | LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928457-A2 | QUINOLINES AND THEIR THERAPEUTIC USE | Argenta Discovery Limited (GB) | 2008-06-11 | — | — | EP | disclosed |
| WO-2007036743-A2 | QUINOLINES AND THEIR THERAPEUTIC USE | ARGENTA DISCOVERY LIMITED (GB) | 2007-04-05 | — | — | WO | disclosed |