Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 5/20 | 0.31 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.30 |
| ▸ | TNF | P01375 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4772679 | 0.81 | MAPT (0.47) | NPC1LMNATP53MAPTRAB9A | |
| SCHEMBL4777706 | 0.79 | NPC1 (0.43) | NPC1LMNATP53MAPTRAB9A | |
| SCHEMBL3776184 | 0.66 | TSHR (0.36) | NPC1MAPTRAB9APTGDR2SMN1; SMN2 | |
| SCHEMBL3770710 | 0.63 | TSHR (0.37) | NPC1MAPTRAB9APTGDR2SMN1; SMN2 | |
| SCHEMBL534117 | 0.62 | P2RX3 (0.40) | SMN1; SMN2 | |
| SCHEMBL168255 | 0.59 | HPGD (0.44) | RORC | |
| SCHEMBL1550705 | 0.58 | CLEC4M (0.58) | TP53MAPT | |
| SCHEMBL3778300 | 0.58 | PSIP1 (0.34) | MAPTSMN1; SMN2RORC | |
| SCHEMBL21381326 | 0.57 | SMN1; SMN2 (0.57) | LMNAMAPTSMN1; SMN2 | |
| SCHEMBL23174361 | 0.57 | ESR1 (0.45) | RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928457-A2 | QUINOLINES AND THEIR THERAPEUTIC USE | Argenta Discovery Limited (GB) | 2008-06-11 | — | — | EP | disclosed |
| WO-2007036743-A2 | QUINOLINES AND THEIR THERAPEUTIC USE | ARGENTA DISCOVERY LIMITED (GB) | 2007-04-05 | — | — | WO | disclosed |