Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 18/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.60 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.60 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.60 |
| ▸ | HTR2A | P28223 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | UBE2N | P61088 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4769905 | 0.92 | HTR6 (0.50) | HTR6CYP3A4ADRA2ACYP2D6ADRA2C | |
| SCHEMBL4774296 | 0.87 | KDM4E (0.54) | HTR6CYP3A4ADRA2ACYP2D6ADRA2C | |
| SCHEMBL4776444 | 0.86 | HTR6 (0.46) | HTR6CYP3A4ADRA2ACYP2D6ADRA2C | |
| SCHEMBL949730 | 0.84 | HTR6 (0.58) | HTR6CYP3A4ADRA2ACYP2D6ADRA2C | |
| SCHEMBL4773184 | 0.84 | HTR6 (0.44) | HTR6CYP3A4ADRA2ACYP2D6ADRA2C | |
| SCHEMBL950533 | 0.83 | HTR6 (0.63) | HTR6HTR2AKDM4EUBE2NDRD2 | |
| SCHEMBL950414 | 0.82 | HTR6 (0.57) | HTR6CYP3A4ADRA2ACYP2D6ADRA2C | |
| SCHEMBL947498 | 0.81 | KDM4E (0.60) | HTR6KDM4EUBE2NALDH1A1 | |
| SCHEMBL4778240 | 0.81 | HTR6 (0.59) | HTR6CYP3A4CYP2D6HTR2AKDM4E | |
| SCHEMBL4774289 | 0.81 | HTR6 (0.47) | HTR6CYP3A4ADRA2ACYP2D6ADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581492-B1 | N-ARYLSULFONYL-3-SUBSTITUTED INDOLES HAVING SEROTONIN RECEPTOR AFFINITY, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEM | SUVEN LIFE SCIENCES LTD (IN) | 2008-07-16 | — | — | EP | disclosed |
| EP-1581538-B1 | TETRACYCLIC 3-SUBSTITUTED INDOLES HAVING SEROTONIN RECEPTOR AFFINITY | SUVEN LIFE SCIENCES LTD (IN) | 2007-02-28 | — | — | EP | disclosed |