Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 17/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | UBE2N | P61088 | 1/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4769905 | 0.94 | HTR6 (0.50) | HTR6CYP3A4ADRA2ACYP2D6ADRA2C | |
| SCHEMBL4773184 | 0.89 | HTR6 (0.44) | HTR6CYP3A4ADRA2ACYP2D6ADRA2C | |
| SCHEMBL4774296 | 0.87 | KDM4E (0.54) | HTR6CYP3A4ADRA2ACYP2D6ADRA2C | |
| SCHEMBL4772681 | 0.86 | HTR6 (0.60) | HTR6CYP3A4ADRA2ACYP2D6ADRA2C | |
| SCHEMBL4778090 | 0.86 | KDM4E (0.52) | HTR6CYP3A4CYP2D6ALDH1A1KDM4E | |
| SCHEMBL4774289 | 0.85 | HTR6 (0.47) | HTR6CYP3A4ADRA2ACYP2D6ADRA2C | |
| SCHEMBL4778240 | 0.84 | HTR6 (0.59) | HTR6CYP3A4CYP2D6HTR2AALDH1A1 | |
| SCHEMBL949730 | 0.82 | HTR6 (0.58) | HTR6CYP3A4ADRA2ACYP2D6ADRA2C | |
| SCHEMBL4770622 | 0.81 | HTR6 (0.54) | HTR6CYP3A4ADRA2ACYP2D6ADRA2C | |
| SCHEMBL945974 | 0.81 | HTR6 (0.54) | HTR6CYP3A4ADRA2ACYP2D6ADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581492-B1 | N-ARYLSULFONYL-3-SUBSTITUTED INDOLES HAVING SEROTONIN RECEPTOR AFFINITY, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEM | SUVEN LIFE SCIENCES LTD (IN) | 2008-07-16 | — | — | EP | disclosed |