Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 4/20 | 0.39 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.39 |
| ▸ | SGK1 | O00141 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | TTK | P33981 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.38 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.37 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14975203 | 0.86 | ERCC1 (0.43) | PARP1KDM4E | |
| SCHEMBL19411854 | 0.76 | HTT (0.49) | PARP1KDM4EALDH1A1HTT | |
| SCHEMBL4428264 | 0.74 | MAPT (0.58) | PARP1KDM4EALDH1A1HTTMAPT | |
| SCHEMBL4208272 | 0.72 | PARP1 (1.00) | PARP1KDM4EALDH1A1HTTAXL | |
| SCHEMBL30532583 | 0.70 | HTT (0.71) | PARP1ALDH1A1HTTAXLCAMKK2 | |
| SCHEMBL3639904 | 0.69 | PARP1 (0.50) | PARP1KDM4EALDH1A1AXLCAMKK2 | |
| SCHEMBL23521242 | 0.67 | FOLH1 (0.53) | KDM4EALDH1A1FOLH1 | |
| SCHEMBL6636942 | 0.67 | ESR2 (0.43) | ALDH1A1HTTMAPTFOLH1 | |
| SCHEMBL27577761 | 0.67 | HTT (0.49) | PARP1ALDH1A1HTTAXLCAMKK2 | |
| SCHEMBL9434145 | 0.66 | ALDH1A1 (0.54) | PARP1ALDH1A1HTTAXLMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881976-A1 | SUBSTITUTED AMIDE DERIVATIVES AS PROTEIN KINASE INHIBITORS | Amgen Inc., (US) | 2008-01-30 | — | — | EP | disclosed |
| WO-2006116713-A1 | SUBSTITUTED AMIDE DERIVATIVES AS PROTEIN KINASE INHIBITORS | AMGEN INC. (US) | 2006-11-02 | — | — | WO | disclosed |