Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 1/20 | 0.50 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.45 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.45 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.45 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.45 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.45 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.43 |
| ▸ | CHI3L1 | P36222 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.43 |
| ▸ | KARS1 | Q15046 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.41 |
| ▸ | LCAT | P04180 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4432257 | 0.99 | CHRM4 (0.49) | CHRM4GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL2146764 | 0.82 | CHRM4 (0.49) | CHRM4GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL6030875 | 0.82 | CHRM4 (0.47) | CHRM4GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL15337848 | 0.79 | GRIN2D (0.51) | CHRM4GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL13622619 | 0.78 | FFAR4 (0.54) | CHRM4GPBAR1KDM4EMEN1HTT | |
| SCHEMBL4429602 | 0.78 | DRD2 (0.51) | PTPN11KDM4E | |
| SCHEMBL18949715 | 0.78 | GRIN2D (0.60) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL2130656 | 0.77 | GRIN2D (0.50) | CHRM4GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL24454255 | 0.77 | GPBAR1 (0.47) | CHRM4GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL803608 | 0.77 | LDHA (0.47) | CHRM4ENPP1PTPN11ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572678-A4 | SUBSTITUTED N-PHENYL SULFONAMIDE BRADYKININ ANTAGONISTS | ELAN PHARM INC (US) | 2008-05-07 | — | — | EP | disclosed |
| EP-1572678-A2 | SUBSTITUTED N-PHENYL SULFONAMIDE BRADYKININ ANTAGONISTS | Elan Pharmaceuticals, Inc. (US) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004056319-A2 | SUBSTITUTED N-PHENYL SULFONAMIDE BRADYKININ ANTAGONISTS | ELAN PHARMACEUTICALS INC. (US) | 2004-07-08 | — | — | WO | disclosed |