Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.37 |
| ▸ | APP | P05067 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL4772888 | 1.00 | ALDH1A1 (0.40) | ALDH1A1KMT2AMEN1L3MBTL1MAPT | |
| SCHEMBL4792970 | 0.96 | MAPT (0.41) | ALDH1A1KMT2AMEN1L3MBTL1MAPT | |
| SCHEMBL4792963 | 0.96 | MAPT (0.41) | ALDH1A1KMT2AMEN1L3MBTL1MAPT | |
| Oxalic Acid SCHEMBL4769349 | 0.86 | ALDH1A1 (0.46) | ALDH1A1KMT2AMEN1L3MBTL1MAPT | |
| Oxalic Acid SCHEMBL4769354 | 0.86 | ALDH1A1 (0.46) | ALDH1A1KMT2AMEN1L3MBTL1MAPT | |
| Oxalic Acid SCHEMBL4793452 | 0.85 | ALDH1A1 (0.43) | ALDH1A1KMT2AMEN1L3MBTL1MAPT | |
| Oxalic Acid SCHEMBL4764765 | 0.84 | MAPT (0.41) | ALDH1A1KMT2AMEN1L3MBTL1MAPT | |
| Oxalic Acid SCHEMBL4764768 | 0.84 | MAPT (0.41) | ALDH1A1KMT2AMEN1L3MBTL1MAPT | |
| Oxalic Acid SCHEMBL6288735 | 0.82 | ALDH1A1 (0.40) | ALDH1A1KMT2AMEN1L3MBTL1MAPT | |
| SCHEMBL4769370 | 0.81 | KDM4E (0.38) | ALDH1A1KMT2AMEN1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1020445-B1 | FUSED PYRIDINE DERIVATIVES | EISAI R&D MAN CO LTD (JP) | 2008-08-13 | — | — | EP | disclosed |
| US-6790844-B2 | MUSCLE RELAXANTS; ANTISEROTONINE AGENT | EISAI CO., LTD (JP) | 2004-09-14 | — | — | US | disclosed |
| US-6340759-B1 | ANTISPASMODIC AGENTS | EISAI CO., LTD. (JP) | 2002-01-22 | — | — | US | disclosed |