Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 4/20 | 0.50 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7494106 | 0.89 | ALDH1A1 (0.53) | ALDH1A1TDP1L3MBTL1GAAPTPN1 | |
| SCHEMBL6578030 | 0.86 | MAPT (0.52) | ALDH1A1TDP1L3MBTL1GAAMRGPRX4 | |
| SCHEMBL12093638 | 0.85 | ALDH1A1 (0.56) | ALDH1A1TDP1L3MBTL1GAAPTPN1 | |
| SCHEMBL1694924 | 0.84 | TDP1 (0.74) | ALDH1A1TDP1L3MBTL1GAAKDM4E | |
| SCHEMBL29369910 | 0.84 | TDP1 (0.74) | ALDH1A1TDP1L3MBTL1GAAKDM4E | |
| SCHEMBL4770864 | 0.83 | ALDH1A1 (0.53) | ALDH1A1TDP1GAAPTPN1NPSR1 | |
| SCHEMBL4775229 | 0.82 | ALDH1A1 (0.57) | ALDH1A1TDP1L3MBTL1GAANPSR1 | |
| SCHEMBL26699212 | 0.82 | MRGPRX4 (0.54) | ALDH1A1TDP1L3MBTL1GAAMRGPRX4 | |
| SCHEMBL4051742 | 0.82 | ALDH1A1 (0.52) | ALDH1A1TDP1GAAPTPN1NPSR1 | |
| SCHEMBL6990963 | 0.82 | ALDH1A1 (0.55) | ALDH1A1TDP1GAAPTPN1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937647-A1 | CONDENSED PYRAZOLE DERIVATIVES AS PPAR AGONISTS II | Inpharmatica Limited (GB) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007036727-A1 | CONDENSED PYRAZOLE DERIVATIVES AS PPAR AGONISTS II | INPHARMATICA LIMITED (GB) | 2007-04-05 | — | — | WO | disclosed |
| WO-2007036727-A1 | CONDENSED PYRAZOLE DERIVATIVES AS PPAR AGONISTS II | INPHARMATICA LIMITED (GB) | 2007-04-05 | — | — | WO | disclosed |