Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | FABP6 | P51161 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 3/20 | 0.36 |
| ▸ | JAK3 | P52333 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL477234 | 0.83 | TP53 (0.39) | ALDH1A1FABP6LMNA | |
| SCHEMBL16418437 | 0.81 | ALDH1A1 (0.51) | ALDH1A1TSHRFABP6JAK2JAK3 | |
| SCHEMBL12626799 | 0.74 | ALDH1A1 (0.54) | ALDH1A1TSHRFABP6JAK2JAK3 | |
| SCHEMBL962492 | 0.74 | ALDH1A1 (0.54) | ALDH1A1TSHRFABP6JAK2JAK3 | |
| SCHEMBL10266067 | 0.72 | ALDH1A1 (0.56) | ALDH1A1TSHRJAK2JAK3MAPK1 | |
| SCHEMBL13741699 | 0.71 | TSHR (0.54) | ALDH1A1TSHRFABP6JAK2JAK3 | |
| SCHEMBL21843867 | 0.71 | ALDH1A1 (0.51) | ALDH1A1TSHRFABP6JAK2JAK3 | |
| SCHEMBL12404074 | 0.71 | TP53 (0.41) | ALDH1A1TSHRFABP6JAK2JAK3 | |
| SCHEMBL12404082 | 0.71 | TP53 (0.41) | ALDH1A1TSHRFABP6JAK2JAK3 | |
| SCHEMBL26309055 | 0.71 | TP53 (0.41) | ALDH1A1TSHRFABP6JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411387-A2 | PYRIMIDINYL AND 1,3,5-TRIAZINYL BENZIMIDAZOLE SULFONAMIDES AND THEIR USE IN CANCER THERAPY | Pathway Therapeutics, Inc. (US) | 2012-02-01 | — | — | EP | disclosed |