SCHEMBL477234

SCHEMBL477234

CC(C)(CCN)NC1CCN(S(C)(=O)=O)CC1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.39
FABP6 P51161 1/20 0.39
EPHX2 P34913 4/20 0.37
KDM1A O60341 1/20 0.37
EPHX1 P07099 1/20 0.37
NPSR1 Q6W5P4 1/20 0.36
ALDH1A1 P00352 2/20 0.36
LMNA P02545 1/20 0.35
ATM Q13315 1/20 0.34
LTA4H P09960 1/20 0.34
SMYD3 Q9H7B4 1/20 0.33
DPP4 P27487 1/20 0.33
DPP8 Q6V1X1 1/20 0.33
DPP9 Q86TI2 1/20 0.33
DPP7 Q9UHL4 1/20 0.33
NSD2 O96028 1/20 0.33
OPRL1 P41146 1/20 0.33
CDK1 P06493 1/20 0.33
CDK4 P11802 1/20 0.33
CCNB1 P14635 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL477334 0.83 ALDH1A1 (0.45) FABP6ALDH1A1LMNA
SCHEMBL12404039 0.79 TP53 (0.46) TP53FABP6EPHX2KDM1AEPHX1
SCHEMBL12543716 0.76 TP53 (0.43) TP53FABP6EPHX2KDM1AEPHX1
SCHEMBL477233 0.73 FABP6 (0.44) TP53FABP6EPHX2KDM1AEPHX1
SCHEMBL21790509 0.73 TDP1 (0.38) TP53FABP6EPHX2KDM1AEPHX1
SCHEMBL13254838 0.72 ALDH1A1 (0.46) TP53FABP6NPSR1ALDH1A1ATM
SCHEMBL29259766 0.71 TP53 (0.48) TP53FABP6EPHX2KDM1AEPHX1
SCHEMBL12404082 0.70 TP53 (0.41) TP53FABP6EPHX2KDM1AEPHX1
SCHEMBL12404074 0.70 TP53 (0.41) TP53FABP6EPHX2KDM1AEPHX1
SCHEMBL26309055 0.70 TP53 (0.41) TP53FABP6EPHX2KDM1AEPHX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2411387-A2 PYRIMIDINYL AND 1,3,5-TRIAZINYL BENZIMIDAZOLE SULFONAMIDES AND THEIR USE IN CANCER THERAPY Pathway Therapeutics, Inc. (US) 2012-02-01 EP claimed
EP-2411387-A2 PYRIMIDINYL AND 1,3,5-TRIAZINYL BENZIMIDAZOLE SULFONAMIDES AND THEIR USE IN CANCER THERAPY Pathway Therapeutics, Inc. (US) 2012-02-01 EP disclosed
WO-2010110685-A2 PYRIMDDINYL AND 1,3,5-TRIAZINYL BENZIMTOAZOLE SULFONAMIDES AND THEIR USE IN CANCER THERAPY PATHWAY THERAPEUTICS LIMITED (NZ) 2010-09-30 WO disclosed