Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | JAK1 | P23458 | 2/20 | 0.42 |
| ▸ | TYK2 | P29597 | 2/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.39 |
| ▸ | IKBKB | O14920 | 3/20 | 0.36 |
| ▸ | CHUK | O15111 | 2/20 | 0.36 |
| ▸ | TTK | P33981 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.34 |
| ▸ | SCD | O00767 | 1/20 | 0.33 |
| ▸ | BMPR2 | Q13873 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1636291 | 0.81 | JAK3 (0.56) | JAK2JAK1TYK2JAK3CSF1R | |
| SCHEMBL1633530 | 0.77 | JAK2 (0.58) | JAK2JAK1TYK2JAK3IKBKB | |
| SCHEMBL4725757 | 0.75 | CA2 (0.39) | — | |
| SCHEMBL1632506 | 0.72 | JAK2 (0.55) | JAK2JAK1TYK2JAK3MCHR1 | |
| SCHEMBL1632504 | 0.72 | JAK2 (0.55) | JAK2JAK1TYK2JAK3MCHR1 | |
| SCHEMBL1633462 | 0.72 | JAK2 (0.55) | JAK2JAK1TYK2JAK3MCHR1 | |
| SCHEMBL4650645 | 0.71 | HTR6 (0.54) | JAK2JAK1TYK2JAK3CSF1R | |
| SCHEMBL1632939 | 0.69 | JAK2 (0.51) | JAK2JAK1TYK2JAK3TNIK | |
| SCHEMBL1634722 | 0.68 | JAK2 (0.54) | JAK2JAK1TYK2JAK3MCHR1 | |
| SCHEMBL13498292 | 0.67 | JAK3 (0.63) | JAK2JAK1TYK2JAK3CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004615-A2 | QUINAZOLINES FOR PDK1 INHIBITION | Novartis AG (CH) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007117607-A2 | QUINAZOLINES FOR PDK1 INHIBITION | NOVARTIS AG (CH) | 2007-10-18 | — | — | WO | disclosed |