Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 5/20 | 0.61 |
| ▸ | AKT1 | P31749 | 11/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 2/20 | 0.56 |
| ▸ | MC5R | P33032 | 1/20 | 0.56 |
| ▸ | MC3R | P41968 | 1/20 | 0.56 |
| ▸ | MC1R | Q01726 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4778157 | 0.93 | AKT1 (0.56) | MC4RAKT1CYP3A4MEN1ALDH1A1 | |
| SCHEMBL4793769 | 0.93 | MAPT (0.57) | MC4RAKT1MEN1ALDH1A1KMT2A | |
| SCHEMBL4793962 | 0.92 | AKT1 (0.59) | MC4RAKT1MEN1ALDH1A1KMT2A | |
| SCHEMBL4778512 | 0.92 | MC4R (0.58) | MC4RAKT1MEN1ALDH1A1KMT2A | |
| SCHEMBL4775178 | 0.90 | AKT1 (0.58) | MC4RAKT1MEN1ALDH1A1KMT2A | |
| SCHEMBL4779235 | 0.88 | MAPT (0.52) | MC4RAKT1CYP3A4MEN1ALDH1A1 | |
| SCHEMBL4776568 | 0.87 | MC4R (0.50) | MC4RAKT1CYP3A4MEN1ALDH1A1 | |
| SCHEMBL4770245 | 0.86 | MC4R (0.68) | MC4RAKT1MEN1ALDH1A1KMT2A | |
| SCHEMBL4909061 | 0.86 | MC4R (0.68) | MC4RAKT1MEN1ALDH1A1KMT2A | |
| SCHEMBL4775603 | 0.85 | MC4R (0.59) | MC4RAKT1MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996550-A2 | CARBOXYAMINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF HDAC DEPENDENT DISEASES | Novartis AG (CH) | 2008-12-03 | — | — | EP | claimed |
| US-20080255149-A1 | Carboxyamine Compounds and Methods of Use Thereof | NOVARTIS AG | 2008-10-16 | — | — | US | claimed |
| WO-2007038459-A2 | CARBOXYAMINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF HDAC DEPENDENT DISEASES | NOVARTIS AG (CH) | 2007-04-05 | — | — | WO | claimed |
| US-20080255149-A1 | Carboxyamine Compounds and Methods of Use Thereof | NOVARTIS AG | 2008-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255149-A1 | Carboxyamine Compounds and Methods of Use Thereof | HNMT, HDAC5, HDAC4 | MC4R 1782/4885AKT1 3114/4885CYP3A4 1320/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.