Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.42 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 3/20 | 0.41 |
| ▸ | CA9 | Q16790 | 3/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5856927 | 0.84 | HDAC4 (0.47) | GAAHTR6LMNATSHRALDH1A1 | |
| SCHEMBL28417721 | 0.84 | GAA (0.53) | GAAHTR6LMNATSHRALDH1A1 | |
| SCHEMBL10780221 | 0.81 | GAA (0.43) | GAAHTR6LMNATSHRSLC22A2 | |
| SCHEMBL4766144 | 0.80 | CA12 (0.55) | GAALMNAALDH1A1NPSR1CA12 | |
| SCHEMBL5859799 | 0.78 | HDAC4 (0.49) | GAAHTR6LMNATSHRCA12 | |
| SCHEMBL11522008 | 0.77 | CYP2D6 (0.49) | GAAHTR6LMNATSHRALDH1A1 | |
| SCHEMBL4768851 | 0.77 | CASP3 (0.53) | GAAHTR6LMNATSHRALDH1A1 | |
| SCHEMBL3943010 | 0.76 | GAA (0.58) | GAAHTR6LMNATSHRSLC22A2 | |
| SCHEMBL3314209 | 0.74 | LMNA (0.70) | GAALMNATSHRALDH1A1MAOA | |
| SCHEMBL11520791 | 0.74 | CYP2D6 (0.46) | GAALMNATSHRALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303496-B9 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| EP-1303496-B1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-12 | — | — | EP | disclosed |