Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 4/20 | 0.47 |
| ▸ | MERTK | Q12866 | 12/20 | 0.46 |
| ▸ | AXL | P30530 | 11/20 | 0.46 |
| ▸ | TYRO3 | Q06418 | 11/20 | 0.46 |
| ▸ | FLT3 | P36888 | 8/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3289873 | 0.92 | CSF1R (0.57) | CSF1RMERTKAXLTYRO3FLT3 | |
| SCHEMBL3293462 | 0.91 | CSF1R (0.48) | CSF1RMERTKAXLTYRO3FLT3 | |
| SCHEMBL3293792 | 0.89 | CSF1R (0.59) | CSF1RMERTKAXLTYRO3FLT3 | |
| SCHEMBL3289954 | 0.89 | ADRB2 (0.55) | CSF1RMERTKAXLTYRO3FLT3 | |
| SCHEMBL4793362 | 0.85 | CSF1R (0.55) | CSF1RMERTKAXLTYRO3FLT3 | |
| SCHEMBL4775380 | 0.85 | CSF1R (0.55) | CSF1RMERTKAXLTYRO3FLT3 | |
| SCHEMBL4778236 | 0.82 | CSF1R (0.49) | CSF1RMERTKAXLTYRO3FLT3 | |
| SCHEMBL11977242 | 0.81 | MERTK (0.47) | MERTKAXLTYRO3FLT3SRC | |
| SCHEMBL3291706 | 0.79 | CSF1R (0.53) | CSF1RMERTKAXLTYRO3FLT3 | |
| SCHEMBL3293220 | 0.79 | CSF1R (0.57) | CSF1RMERTKAXLTYRO3FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945637-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-07-23 | — | — | EP | claimed |
| WO-2007033137-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-03-22 | — | — | WO | claimed |
| EP-1945637-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007033137-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-03-22 | — | — | WO | disclosed |