SCHEMBL4773722

SCHEMBL4773722

O=C(C1CCN(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)CC1)N(CCCN1CCC(Cc2ccc(F)cc2)CC1)c1ccc(Cl)c(Cl)c1

nearest known ligand 0.75

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
CCR5 P51681 20/20 0.75

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL5119654 0.97 CCR5 (0.71) CCR5
Trifluoroacetic Acid SCHEMBL4777547 0.91 CCR5 (0.79) CCR5
Trifluoroacetic Acid SCHEMBL4771411 0.90 CCR5 (0.73) CCR5
SCHEMBL4776678 0.89 CCR5 (0.71) CCR5
Trifluoroacetic Acid SCHEMBL4776673 0.88 CCR5 (0.75) CCR5
SCHEMBL7515679 0.86 CCR5 (0.75) CCR5
SCHEMBL4778085 0.86 CCR5 (1.00) CCR5
Trifluoroacetic Acid SCHEMBL4771568 0.85 CCR5 (0.71) CCR5
Trifluoroacetic Acid SCHEMBL4771581 0.85 CCR5 (0.91) CCR5
Trifluoroacetic Acid SCHEMBL4776716 0.84 CCR5 (0.77) CCR5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1886994-A1 Cyclic amine compounds as CCR5 antagonists Takeda Pharmaceutical Company Limited (JP) 2008-02-13 EP disclosed