Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.45 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 9/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL230319 | 0.83 | NR1H2 (0.52) | NR1H2NR1H3TDP1MAPTSMN1; SMN2 | |
| SCHEMBL2067842 | 0.79 | GBA1 (0.46) | TDP1SMN1; SMN2KMT2AKDM4ETSHR | |
| SCHEMBL28308405 | 0.75 | MAPT (0.59) | TDP1MAPTSMN1; SMN2LIN28AKCNA5 | |
| SCHEMBL4774563 | 0.74 | POLB (0.54) | TDP1MAPTSMN1; SMN2ESR1KMT2A | |
| SCHEMBL4774947 | 0.73 | HCAR3 (0.38) | MAPTSMN1; SMN2 | |
| SCHEMBL18301470 | 0.72 | SMN1; SMN2 (0.59) | TDP1MAPTSMN1; SMN2LIN28ACHRNA7 | |
| SCHEMBL5772539 | 0.72 | SMN1; SMN2 (0.50) | NR1H2NR1H3TDP1MAPTSMN1; SMN2 | |
| SCHEMBL4777939 | 0.70 | CYP2D6 (0.43) | SMN1; SMN2KMT2AKDM4EPOLBTSHR | |
| SCHEMBL804309 | 0.69 | TDP1 (0.70) | NR1H2NR1H3TDP1MAPTSMN1; SMN2 | |
| SCHEMBL29877048 | 0.69 | TDP1 (0.70) | NR1H2NR1H3TDP1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1991530-A1 | CINNOLINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS | Amgen Inc. (US) | 2008-11-19 | — | — | EP | claimed |
| WO-2007098169-A1 | CINNOLINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS | AMGEN INC. (US) | 2007-08-30 | — | — | WO | claimed |
| EP-1991530-A1 | CINNOLINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS | Amgen Inc. (US) | 2008-11-19 | — | — | EP | disclosed |
| WO-2007098169-A1 | CINNOLINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS | AMGEN INC. (US) | 2007-08-30 | — | — | WO | disclosed |