Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.44 |
| ▸ | BRAF | P15056 | 5/20 | 0.42 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.39 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | DDR2 | Q16832 | 3/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.37 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4354964 | 0.80 | EGFR (0.46) | KDRAURKBIKBKETBK1 | |
| SCHEMBL25882292 | 0.68 | SCN9A (0.51) | BRAFDDR2 | |
| SCHEMBL13336325 | 0.66 | MAP4K1 (0.45) | MAP4K1KDRTBK1CDK1CCNA2 | |
| SCHEMBL4358324 | 0.66 | PIK3CA (0.42) | IKBKETBK1 | |
| SCHEMBL5909044 | 0.66 | FBP1 (0.58) | BRAFKDRCDK1 | |
| SCHEMBL12725589 | 0.66 | MAPK10 (0.55) | MAP4K1MAP4K3CCNA2CDK2 | |
| SCHEMBL1632778 | 0.65 | MAPK10 (0.53) | MAP4K1CCNA2CDK2 | |
| SCHEMBL2741577 | 0.65 | BRAF (0.60) | MAP4K1BRAFMAP3K5DGAT1KDR | |
| SCHEMBL5495505 | 0.65 | ADRB2 (0.58) | BRAFMAP3K5DGAT1KDRAURKB | |
| SCHEMBL13362987 | 0.65 | MAP3K5 (0.62) | BRAFMAP3K5KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009078-A2 | 4,6-DL- AND 2,4,6-TRISUBSTITUTED QUINAZOLINE DERIVATIVES USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2008-01-24 | — | — | WO | disclosed |