Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.41 |
| ▸ | EBP | Q15125 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 4/20 | 0.39 |
| ▸ | JAK1 | P23458 | 4/20 | 0.39 |
| ▸ | TYK2 | P29597 | 3/20 | 0.39 |
| ▸ | JAK3 | P52333 | 3/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4774256 | 0.94 | TGFBR1 (0.42) | TGFBR1ACVR1EBPSIGMAR1SMN1; SMN2 | |
| SCHEMBL4766895 | 0.92 | TGFBR1 (0.44) | TGFBR1ACVR1JAK2JAK1TYK2 | |
| SCHEMBL4766894 | 0.92 | TGFBR1 (0.44) | TGFBR1ACVR1JAK2JAK1TYK2 | |
| SCHEMBL4772534 | 0.88 | SMN1; SMN2 (0.48) | TGFBR1ACVR1EBPSIGMAR1TMEM97 | |
| SCHEMBL4763684 | 0.86 | TGFBR1 (0.45) | TGFBR1ACVR1EBPSIGMAR1TMEM97 | |
| SCHEMBL2910499 | 0.83 | SIGMAR1 (0.53) | EBPSIGMAR1TMEM97 | |
| SCHEMBL4768736 | 0.83 | MEN1 (0.42) | TGFBR1ACVR1SMN1; SMN2KCNH2 | |
| SCHEMBL4763764 | 0.82 | TGFBR1 (0.49) | TGFBR1ACVR1SMN1; SMN2JAK2JAK1 | |
| SCHEMBL2910440 | 0.80 | SIGMAR1 (0.50) | EBPSIGMAR1TMEM97SMN1; SMN2KCNH2 | |
| SCHEMBL4774242 | 0.80 | KMT2A (0.54) | TGFBR1ACVR1JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1400513-B1 | UNSYMMETRICAL CYCLIC DIAMINE COMPOUND | KOWA CO (JP) | 2008-01-09 | — | — | EP | disclosed |
| EP-1400513-A1 | UNSYMMETRICAL CYCLIC DIAMINE COMPOUND | Kowa Co., Ltd. (JP) | 2004-03-24 | — | — | EP | disclosed |