Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.76 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.40 |
| ▸ | EIF4E | P06730 | 1/20 | 0.35 |
| ▸ | F2RL3 | Q96RI0 | 2/20 | 0.35 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 6/20 | 0.34 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.32 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.32 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4774874 | 1.00 | CHRM1 (0.76) | CHRM1KCNH2PTGS1SLC6A2SLC6A4 | |
| SCHEMBL508066 | 0.88 | CHRM1 (0.94) | CHRM1KCNH2PTGS1SLC6A2SLC6A4 | |
| Pretomanid SCHEMBL14004006 | 0.87 | CHRM1 (1.00) | CHRM1KCNH2PTGS1SLC6A2SLC6A4 | |
| Pretomanid SCHEMBL2983011 | 0.87 | CHRM1 (1.00) | CHRM1KCNH2PTGS1SLC6A2SLC6A4 | |
| SCHEMBL508462 | 0.86 | CHRM1 (0.75) | CHRM1KCNH2PTGS1SLC6A2SLC6A4 | |
| SCHEMBL508007 | 0.85 | CHRM1 (0.73) | CHRM1KCNH2PTGS1SLC6A2SLC6A4 | |
| SCHEMBL507542 | 0.84 | CHRM1 (0.94) | CHRM1KCNH2PTGS1SLC6A2SLC6A4 | |
| SCHEMBL1160458 | 0.84 | CHRM1 (0.94) | CHRM1KCNH2PTGS1SLC6A2SLC6A4 | |
| SCHEMBL508172 | 0.84 | CHRM1 (0.72) | CHRM1KCNH2PTGS1SLC6A2SLC6A4 | |
| SCHEMBL508717 | 0.84 | CHRM1 (0.80) | CHRM1KCNH2PTGS1SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080275035-A1 | Nitroimidazole Compounds | JIRICEK JAN | 2008-11-06 | — | — | US | disclosed |
| US-20080275035-A1 | Nitroimidazole Compounds | JIRICEK JAN | 2008-11-06 | — | — | US | disclosed |
| US-20080275035-A1 | Nitroimidazole Compounds | JIRICEK JAN | 2008-11-06 | — | — | US | disclosed |
| EP-1984369-A2 | NITROIMIDAZOLE COMPOUNDS | Novartis AG (CH) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007075872-A2 | NITROIMIDAZOLE COMPOUNDS | NOVARTIS AG (CH) | 2007-07-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080275035-A1 | Nitroimidazole Compounds | NQO2, NQO1, MT-ND2 | CHRM1 1746/4885KCNH2 1884/4885PTGS1 745/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.