MT-ND2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Auraptene (SCHEMBL2535029)	1.00	5/20
Auraptene (SCHEMBL2535034)	1.00	5/20
SCHEMBL8491443	0.56	4/20
SCHEMBL8489900	0.52	4/20
SCHEMBL8489907	0.52	4/20
SCHEMBL8492838	0.52	4/20
SCHEMBL8492845	0.52	4/20
SCHEMBL8489902	0.51	4/20
SCHEMBL8489908	0.51	4/20
SCHEMBL8491154	0.51	4/20
SCHEMBL8491160	0.51	4/20
SCHEMBL8491619	0.50	4/20
SCHEMBL8491624	0.50	4/20
SCHEMBL8491634	0.50	4/20
7-Prenyloxycoumarin (SCHEMBL4898255)	0.79	3/20
SCHEMBL712741	0.57	3/20
Geiparvarin (SCHEMBL2532495)	0.56	3/20
SCHEMBL6267768	0.55	3/20
SCHEMBL8493191	0.55	3/20
SCHEMBL8493327	0.55	3/20

Clinical trials — most relevant to MT-ND2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Phase III Trial of Coenzyme Q10 in Mitochondrial Disease	PHASE3	COMPLETED
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve)	PHASE3	WITHDRAWN
A Phase 3, Multicenter, Randomized, Double-Masked, Sham-Controlled Clinical Trial for Leber's Hereditary Optic Neuropathy (LHON) Associated With ND4 Mutation	PHASE3	ACTIVE_NOT_RECRUITING
A Study to Evaluate Vitamin B3 Derivative to Treat Mitochondrial Myopathy	PHASE2	ACTIVE_NOT_RECRUITING
A Study of Bezafibrate in Mitochondrial Myopathy	PHASE2	COMPLETED
Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder	PHASE2	WITHDRAWN
Trial of Nicotinamide Riboside and Co-enzyme Q10 in Chronic Kidney Disease	PHASE2	COMPLETED
Efficacy of KL1333 in Adult Patients With Primary Mitochondrial Disease	PHASE2	RECRUITING
Does Clinical Treatment of Mitochondrial Dysfunction Impact Autism Spectrum Disorder (ASD)?	PHASE1	UNKNOWN
Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine	nan	COMPLETED
The Natural History of Mitochondrial Diseases	nan	RECRUITING
Identification of Large-Scale Mutations of POLG Gene by QMPSF in Patients With Mitochondrial DNA Instability.	nan	UNKNOWN
MITOMICS : a Multi-OMICS Approach for the Diagnosis of Mitochondrial Diseases	nan	RECRUITING
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)	nan	RECRUITING
Survey on Supplement Use in Mitochondrial Disease	nan	COMPLETED
Diagnostic Odyssey Survey 2	nan	COMPLETED
Tissue Sample Study for Mitochondrial Disorders	nan	ENROLLING_BY_INVITATION
Natural History in Primary Mitochondrial Myopathies	nan	RECRUITING
GDF-15 as a Biomarker for Mitochondrial Disease	nan	COMPLETED
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes	nan	NOT_YET_RECRUITING
Nicotinamide Riboside and Mitochondrial Biogenesis	nan	COMPLETED
Identification of New Candidate Genes in Patients With Mitochondrial Disease by High Resolution Chromosome Analysis on DNA Chip	nan	COMPLETED
Calf Muscle Strength in Mitochondrial Diseases	nan	COMPLETED
Red Light Ptosis Proof-of-Concept	nan	UNKNOWN
Mitoquines in COPD	nan	UNKNOWN
Evaluation of Impact of Disease and Visual Disability on Quality of Life and Loss of Independence of Patients Living in France With Leber's Hereditary Optic Neuropathy (LHON) Through Qualitative and Quantitative Data Collection	nan	COMPLETED
Ccf mtDNA as a Neurodegenerative Biomarker	nan	UNKNOWN
Exercise Training Effects on Muscle Function in Adults With Mitochondrial Myopathy	nan	RECRUITING
Cardiac Mitochondrial Function in Explanted Human Hearts	nan	UNKNOWN
Development of a New Technique for Quantifying Mitochondrial DNA in Single Muscle Fibers	nan	NOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a MT-ND2 binder may also engage these)

Protein	Name	Similarity
Q95704	—	1.000	Q95704 →
O21798	—	1.000	O21798 →
Q34799	—	1.000	Q34799 →
Q9T9X8	—	1.000	Q9T9X8 →
Q9T9X1	—	1.000	Q9T9X1 →
Q9T9Y9	—	1.000	Q9T9Y9 →
P92691	—	1.000	P92691 →
Q330B3	—	0.998	Q330B3 →
O79671	—	0.997	O79671 →
Q36451	—	0.997	Q36451 →
Q330B1	—	0.997	Q330B1 →
Q330D8	—	0.997	Q330D8 →
Q2I3H3	—	0.996	Q2I3H3 →
P11662	—	0.996	P11662 →
Q85PQ7	—	0.996	Q85PQ7 →
Q8W9N5	—	0.995	Q8W9N5 →
Q32ZZ4	—	0.995	Q32ZZ4 →
Q71MY2	—	0.994	Q71MY2 →
Q330E9	—	0.994	Q330E9 →
Q85PS1	—	0.994	Q85PS1 →
Q8LX31	—	0.994	Q8LX31 →
P92660	—	0.994	P92660 →
Q330A5	—	0.994	Q330A5 →
Q330A8	—	0.994	Q330A8 →
Q330A0	—	0.994	Q330A0 →
Q330C4	—	0.993	Q330C4 →
O79428	—	0.993	O79428 →
Q330E5	—	0.993	Q330E5 →
Q94V92	—	0.993	Q94V92 →
Q330G8	—	0.993	Q330G8 →