Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.32 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.32 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.32 |
| ▸ | IKBKB | O14920 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4261323 | 0.94 | ALDH1A1 (0.37) | ALDH1A1TSHRHTTMAPTKDM4E | |
| SCHEMBL4256288 | 0.85 | KDM4E (0.41) | ALDH1A1HTTMAPTKDM4ENPC1 | |
| SCHEMBL4181610 | 0.85 | ALDH1A1 (0.39) | ALDH1A1TSHRHTTMAPTKDM4E | |
| SCHEMBL4181600 | 0.85 | ALDH1A1 (0.39) | ALDH1A1TSHRHTTMAPTKDM4E | |
| SCHEMBL4774303 | 0.79 | ALDH1A1 (0.38) | ALDH1A1TSHRHTTMAPTKDM4E | |
| SCHEMBL4774305 | 0.79 | ALDH1A1 (0.38) | ALDH1A1TSHRHTTMAPTKDM4E | |
| SCHEMBL4176316 | 0.75 | KDM4E (0.44) | ALDH1A1HTTMAPTKDM4ENPC1 | |
| SCHEMBL4846697 | 0.74 | ALDH1A1 (0.44) | ALDH1A1TSHRHTTMAPTKDM4E | |
| SCHEMBL4846705 | 0.74 | ALDH1A1 (0.44) | ALDH1A1TSHRHTTMAPTKDM4E | |
| SCHEMBL4773050 | 0.74 | HDAC1 (0.37) | HTTMAPTKDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1986646-A1 | NOVEL AZACYCLY-SUBSTITUTED ARYLTHIENOPYRIMIDINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | Sanofi-Aventis (FR) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007093363-A1 | NOVEL AZACYCLY-SUBSTITUTED ARYLTHIENOPYRIMIDINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | SANOFI-AVENTIS (DE) | 2007-08-23 | — | — | WO | disclosed |