Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | CCR6 | P51684 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2789887 | 0.85 | DYRK3 (0.46) | GPR84POLBLMNAHDAC3HDAC1 | |
| SCHEMBL2789886 | 0.85 | DYRK3 (0.46) | GPR84POLBLMNAHDAC3HDAC1 | |
| SCHEMBL4772646 | 0.81 | KMT2A (0.52) | KMT2A | |
| SCHEMBL4768062 | 0.73 | DYRK3 (0.38) | POLBKMT2AMEN1SMN1; SMN2BACE1 | |
| SCHEMBL4770645 | 0.73 | NEK2 (0.39) | — | |
| SCHEMBL5570153 | 0.72 | CISD1 (0.40) | GPR84LMNAKMT2ARPS6KB1CSNK2A2 | |
| SCHEMBL5570152 | 0.72 | CISD1 (0.40) | GPR84LMNAKMT2ARPS6KB1CSNK2A2 | |
| SCHEMBL4867626 | 0.72 | ALOX5 (0.43) | CSNK2A2CSNK2A1RAB9A | |
| SCHEMBL4871649 | 0.72 | PIK3CD (0.45) | POLBLMNAHDAC1HDAC6CSNK2A2 | |
| SCHEMBL4928228 | 0.72 | GSK3B (0.47) | GPR84KMT2ARPS6KB1CSNK2A2CSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567112-B1 | THIAZOLIDIN-4-ONES FOR INHIBITING hYAK3 PROTEINS | SMITHKLINE BEECHAM CORP (US) | 2008-10-15 | — | — | EP | claimed |