Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NEK2 | P51955 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 14/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | CDK9 | P50750 | 2/20 | 0.36 |
| ▸ | RET | P07949 | 2/20 | 0.36 |
| ▸ | FLT1 | P17948 | 2/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.35 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4774422 | 0.91 | CYP2C9 (0.36) | KDRMAPTGLO1 | |
| SCHEMBL2788319 | 0.85 | PIK3CD (0.43) | NEK2KDRMAPTCCNT1CCNE1 | |
| SCHEMBL2788317 | 0.85 | PIK3CD (0.43) | NEK2KDRMAPTCCNT1CCNE1 | |
| SCHEMBL4765880 | 0.82 | ROCK1 (0.43) | CCNT1CCNE1CDK2CDK9 | |
| SCHEMBL2788315 | 0.76 | PIK3CD (0.45) | MAPTCCNT1CCNE1CDK2CDK9 | |
| SCHEMBL2788312 | 0.76 | PIK3CD (0.45) | MAPTCCNT1CCNE1CDK2CDK9 | |
| SCHEMBL4765576 | 0.74 | CHKA (0.41) | MAPTCCNT1CDK9PDGFRBPDGFRA | |
| SCHEMBL4775747 | 0.73 | GPR84 (0.38) | — | |
| SCHEMBL4768062 | 0.72 | DYRK3 (0.38) | KDRMAPT | |
| SCHEMBL4776063 | 0.72 | NQO1 (0.43) | MAPTCCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567112-B1 | THIAZOLIDIN-4-ONES FOR INHIBITING hYAK3 PROTEINS | SMITHKLINE BEECHAM CORP (US) | 2008-10-15 | — | — | EP | claimed |