Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
| ▸ | CCR1 | P32246 | 1/20 | 0.33 |
| ▸ | PRCP | P42785 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4775771 | 1.00 | KMT2A (0.36) | KMT2AMEN1CYP2D6CYP1A2CYP3A4 | |
| SCHEMBL4774550 | 0.94 | MEN1 (0.39) | KMT2AMEN1CYP2D6CYP1A2CYP3A4 | |
| SCHEMBL4774556 | 0.94 | MEN1 (0.39) | KMT2AMEN1CYP2D6CYP1A2CYP3A4 | |
| SCHEMBL4021306 | 0.84 | GRIN2B (0.43) | CYP2D6ALDH1A1HRH1KCNH2GRIN2B | |
| SCHEMBL4021309 | 0.84 | GRIN2B (0.43) | CYP2D6ALDH1A1HRH1KCNH2GRIN2B | |
| SCHEMBL4021421 | 0.82 | ALDH1A1 (0.45) | KMT2AMEN1CYP2D6ALDH1A1HRH1 | |
| SCHEMBL4022406 | 0.82 | CYP1A2 (0.49) | KMT2AMEN1CYP2D6CYP1A2CYP3A4 | |
| SCHEMBL4028137 | 0.82 | RORC (0.37) | KMT2AMEN1CYP2D6CYP1A2CYP3A4 | |
| SCHEMBL4022405 | 0.82 | CYP1A2 (0.49) | KMT2AMEN1CYP2D6CYP1A2CYP3A4 | |
| SCHEMBL4021425 | 0.82 | ALDH1A1 (0.45) | KMT2AMEN1CYP2D6ALDH1A1HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1962846-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007059323-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-24 | — | — | WO | disclosed |