Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17110905 | 0.88 | AKR1C3 (0.55) | MAPK1TP53MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL17110898 | 0.84 | MEN1 (0.68) | MAPK1TSHRMAPTALDH1A1CYP1A2 | |
| SCHEMBL15635777 | 0.83 | LMNA (0.58) | MAPK1LMNAABCG2ALDH1A1CYP1A2 | |
| SCHEMBL15635512 | 0.83 | LMNA (0.54) | MAPK1LMNATP53MAPTKDM4E | |
| SCHEMBL17112624 | 0.82 | MAPT (0.50) | MAPK1LMNATP53MAPTALDH1A1 | |
| SCHEMBL15636037 | 0.82 | DHODH (0.58) | LMNAMAPTALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL5252367 | 0.81 | MEN1 (0.71) | PDE5AMAPK1LMNATP53TSHR | |
| SCHEMBL869587 | 0.80 | DHODH (0.46) | MAPK1LMNAMAPTABCG2ALDH1A1 | |
| SCHEMBL870223 | 0.80 | DHODH (0.53) | LMNAALDH1A1CYP1A2PKMMEN1 | |
| SCHEMBL17110923 | 0.80 | MEN1 (0.58) | MAPK1TSHRMAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080227797-A1 | Pyridopyrimidine Derivatives as Pde4 Inhibitors for the Treatment of Inflammatory and Immune Diseases | ASTRAZENECA AB (SE) | 2008-09-18 | — | — | US | disclosed |
| CN-101258152-A | Pyridopyrimidine derivatives as PDE4 inhibitors for the treatment of inflammatory and immune diseases | ASTRAZENECA AB (SE) | 2008-09-03 | — | — | CN | disclosed |
| EP-1922318-A1 | PYRIDOPYRIMIDINE DERIVATIVES AS PDE4 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY AND' IMMUNE DISEASES | AstraZeneca AB (SE) | 2008-05-21 | — | — | EP | disclosed |
| WO-2007004958-A1 | PYRIDOPYRIMIDINE DERIVATIVES AS PDE4 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY AND' IMMUNE DISEASES | ASTRAZENECA AB (SE) | 2007-01-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080227797-A1 | Pyridopyrimidine Derivatives as Pde4 Inhibitors for the Treatment of Inflammatory and Immune Diseases | PDE4A, PDE4B, PDE5A | PDE5A 3/4885MAPK1 381/4885LMNA 4229/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.