Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspartic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM8 | O00222 | 1/20 | 0.40 |
| ▸ | GRM6 | O15303 | 1/20 | 0.40 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.38 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspartic Acid SCHEMBL27759943 | 1.00 | GRM8 (0.40) | GRM8GRM6GRM7GRM4GRIK1 | |
| SCHEMBL771738 | 0.94 | CA4 (0.39) | GRM8GRM6GRM7GRM4FOLH1 | |
| SCHEMBL771739 | 0.94 | CA4 (0.39) | GRM8GRM6GRM7GRM4FOLH1 | |
| SCHEMBL4297049 | 0.94 | CA4 (0.39) | GRM8GRM6GRM7GRM4FOLH1 | |
| SCHEMBL28006119 | 0.92 | CA4 (0.38) | GRM8GRM6GRM7GRM4FOLH1 | |
| SCHEMBL28278353 | 0.89 | CA4 (0.40) | GRM8GRM6GRM7GRM4FOLH1 | |
| Aspartic Acid SCHEMBL28664670 | 0.85 | CA4 (0.56) | GRM8GRM6GRM7GRM4GRIK1 | |
| Aspartic Acid SCHEMBL23362892 | 0.82 | GRM8 (0.43) | GRM8GRM6GRM7GRM4GRIK1 | |
| Aspartic Acid SCHEMBL3379835 | 0.82 | GRM8 (0.48) | GRM8GRM6GRM7GRM4GRIK1 | |
| Aspartic Acid SCHEMBL3379838 | 0.82 | GRM8 (0.48) | GRM8GRM6GRM7GRM4GRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899472-A1 | ALTERED GLYOXYLATE SHUNT FOR IMPROVED PRODUCTION OF ASPARTATE-DERIVED AMINO ACIDS AND CHEMICALS | Archer-Daniels-Midland Company (US) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007001982-A1 | ALTERED GLYOXYLATE SHUNT FOR IMPROVED PRODUCTION OF ASPARTATE-DERIVED AMINO ACIDS AND CHEMICALS | ARCHER-DANIELS-MIDLAND COMPANY (US) | 2007-01-04 | — | — | WO | disclosed |