Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 18/20 | 0.56 |
| ▸ | FLT3 | P36888 | 2/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | KIT | P10721 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286892 | 0.95 | MET (0.61) | METFLT3KDRROCK2 | |
| Hydrochloric Acid SCHEMBL4773711 | 0.94 | MET (0.60) | METFLT3KDRROCK2 | |
| SCHEMBL4940558 | 0.85 | MET (0.59) | METFLT3 | |
| SCHEMBL8288991 | 0.82 | MET (0.65) | METFLT3KDRROCK2 | |
| SCHEMBL4769899 | 0.82 | MET (0.53) | METFLT3EGFRPDGFRBKIT | |
| SCHEMBL8288936 | 0.81 | MET (0.54) | METFLT3EGFRPDGFRBKIT | |
| SCHEMBL4822805 | 0.80 | MET (0.67) | METFLT3KDRROCK2 | |
| SCHEMBL4775389 | 0.79 | MET (0.71) | METFLT3EGFRPDGFRBKIT | |
| SCHEMBL14028130 | 0.77 | MET (0.56) | METFLT3 | |
| SCHEMBL4769553 | 0.76 | MET (0.61) | METFLT3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1709043-B1 | PYRROLOPYRIDINE-SUBSTITUTED BENZOL DERIVATIVES FOR TREATING CARDIOVASCULAR DISEASES | BAYER HEALTHCARE AG (DE) | 2008-12-03 | — | — | EP | disclosed |
| EP-1709043-A1 | PYRROLOPYRIDINE-SUBSTITUTED BENZOL DERIVATIVES FOR TREATING CARDIOVASCULAR DISEASES | Bayer HealthCare AG (DE) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005058891-A1 | PYRROLOPYRIDINE-SUBSTITUTED BENZOL DERIVATIVES FOR TREATING CARDIOVASCULAR DISEASES | BAYER HEALTHCARE AG (DE) | 2005-06-30 | — | — | WO | disclosed |