Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 3/20 | 0.49 |
| ▸ | PARP14 | Q460N5 | 5/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.42 |
| ▸ | TNKS | O95271 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | ESRRG | P62508 | 1/20 | 0.39 |
| ▸ | TDP2 | O95551 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.38 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4140115 | 0.83 | TDP2 (0.45) | TDP2FAAHDPP4DPP8 | |
| SCHEMBL4140118 | 0.83 | TDP2 (0.45) | TDP2FAAHDPP4DPP8 | |
| SCHEMBL4136321 | 0.83 | TDP2 (0.45) | TDP2FAAHDPP4DPP8 | |
| SCHEMBL4144270 | 0.83 | TDP2 (0.45) | TDP2FAAHDPP4DPP8 | |
| SCHEMBL4142275 | 0.81 | PARP14 (0.43) | PARP14PARP10TNKSPARP1TDP2 | |
| SCHEMBL4136275 | 0.80 | GRIN2B (0.49) | GRIN2BFAAHDPP4DPP8 | |
| SCHEMBL4133418 | 0.76 | L3MBTL3 (0.51) | GRIN2BTDP2FAAH | |
| SCHEMBL3324704 | 0.75 | TDP2 (0.41) | TDP2FAAHDPP4DPP8 | |
| SCHEMBL3324698 | 0.75 | TDP2 (0.41) | TDP2FAAHDPP4DPP8 | |
| SCHEMBL3323263 | 0.75 | TDP2 (0.41) | TDP2FAAHDPP4DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007749-A2 | TETRALINES ANTAGONISTS OF THE H-3 RECEPTOR | Pfizer Products Inc. (US) | 2008-12-31 | — | — | EP | claimed |
| WO-2007105053-A2 | TETRALINES ANTAGONISTS OF THE H-3 RECEPTOR | PFIZER PRODUCTS INC. (US) | 2007-09-20 | — | — | WO | claimed |