Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4772589 | 0.89 | MAPT (0.33) | PDE10AMAPTTSHRRECQLNPSR1 | |
| SCHEMBL27682178 | 0.88 | PDE10A (0.35) | PDE10AMAPTTSHRRECQLNPSR1 | |
| SCHEMBL4776451 | 0.86 | MAT2A (0.30) | — | |
| SCHEMBL27682253 | 0.85 | PDE10A (0.36) | PDE10AMAPTTSHRRECQLNPSR1 | |
| SCHEMBL4777608 | 0.84 | MAPK1 (0.33) | PDE10AMAPTTSHRRECQLNPSR1 | |
| SCHEMBL4771822 | 0.84 | MAPT (0.35) | PDE10AMAPTTSHRRECQLNPSR1 | |
| SCHEMBL4770121 | 0.83 | PDE10A (0.33) | PDE10AMAPTTSHRRECQLNPSR1 | |
| SCHEMBL4772227 | 0.82 | MAPT (0.42) | MAPTTSHRNPSR1 | |
| SCHEMBL27682201 | 0.80 | KDM4E (0.36) | MAPT | |
| SCHEMBL4769988 | 0.80 | PDE10A (0.30) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1763528-B1 | PYRAZOLOPYRIDINE DERIVATIVES | ASTELLAS PHARMA INC (JP) | 2008-11-26 | — | — | EP | disclosed |
| CN-1980927-A | Pyrazolopyridine derivatives | ASTELLAS PHARMA INC (JP) | 2007-06-13 | — | — | CN | disclosed |
| EP-1763528-A1 | PYRAZOLOPYRIDINE DERIVATIVES | Astellas Pharma Inc. (JP) | 2007-03-21 | — | — | EP | disclosed |
| WO-2006004188-A1 | PYRAZOLOPYRIDINE DERIVATIVES | ASTELLAS PHARMA INC. (JP) | 2006-01-12 | — | — | WO | disclosed |