Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | CASP1 | P29466 | 2/20 | 0.36 |
| ▸ | CASP7 | P55210 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.33 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27682184 | 0.88 | KDM4E (0.36) | KDM4EMAPK1CASP1CASP7ATM | |
| SCHEMBL5367661 | 0.88 | KDM4E (0.38) | KDM4EMAPK1CASP1CASP7ATM | |
| SCHEMBL4778930 | 0.87 | KDM4E (0.43) | KDM4EMAPK1CASP1CASP7ATM | |
| SCHEMBL27682170 | 0.85 | TBXAS1 (0.43) | KDM4EMAPK1CASP1CASP7ATM | |
| SCHEMBL4771822 | 0.85 | MAPT (0.35) | MAPK1L3MBTL1ALDH1A1MAPTHPGD | |
| SCHEMBL27682198 | 0.84 | NR1H2 (0.37) | KDM4EMAPK1CASP1CASP7ATM | |
| SCHEMBL4774540 | 0.84 | KDM4E (0.35) | KDM4EMAPK1CASP1CASP7ATM | |
| SCHEMBL4772359 | 0.82 | KDM4E (0.45) | KDM4EMAPK1ALDH1A1MAPTHPGD | |
| SCHEMBL27682217 | 0.82 | PRKAA2 (0.36) | ATMPIK3CAMTOR | |
| SCHEMBL4776264 | 0.82 | SMN1; SMN2 (0.33) | KDM4EMAPK1CASP1CASP7ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1980927-A | Pyrazolopyridine derivatives | ASTELLAS PHARMA INC (JP) | 2007-06-13 | — | — | CN | disclosed |