Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.46 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.44 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4021961 | 0.98 | KDM4E (0.49) | HRH3KDM4EPOLBALDH1A1KDM2B | |
| Benzaldehyde SCHEMBL4772493 | 0.90 | KDM4E (0.42) | HRH3KDM4EPOLBALDH1A1KDM2B | |
| SCHEMBL4021144 | 0.83 | HRH3 (0.43) | HRH3KDM4EPOLBALDH1A1KDM2B | |
| SCHEMBL4022028 | 0.80 | KMT2A (0.61) | ALDH1A1L3MBTL1 | |
| SCHEMBL4026478 | 0.76 | KMT2A (0.44) | ALDH1A1 | |
| SCHEMBL4024282 | 0.75 | SLC18A3 (0.45) | ALDH1A1SLC18A3LMNA | |
| SCHEMBL4022301 | 0.75 | MEN1 (0.40) | ALDH1A1 | |
| SCHEMBL4772415 | 0.75 | RORC (0.64) | ALDH1A1LMNA | |
| SCHEMBL4022773 | 0.75 | RORC (0.64) | ALDH1A1LMNA | |
| SCHEMBL4026119 | 0.75 | SLC18A3 (0.45) | ALDH1A1SLC18A3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1962846-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-09-03 | — | — | EP | claimed |
| WO-2007059323-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-24 | — | — | WO | claimed |
| EP-1962846-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007059323-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-24 | — | — | WO | disclosed |