Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 5/20 | 0.42 |
| ▸ | CDK8 | P49336 | 5/20 | 0.42 |
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.38 |
| ▸ | PLK4 | O00444 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 2/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.38 |
| ▸ | PAK4 | O96013 | 2/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.38 |
| ▸ | LCK | P06239 | 2/20 | 0.38 |
| ▸ | CSF1R | P07333 | 2/20 | 0.38 |
| ▸ | RET | P07949 | 2/20 | 0.38 |
| ▸ | MET | P08581 | 2/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.38 |
| ▸ | KIT | P10721 | 2/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.38 |
| ▸ | FLT1 | P17948 | 2/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.38 |
| ▸ | TYK2 | P29597 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4776882 | 1.00 | CCNC (0.42) | CCNCCDK8KDRHDAC6PLK4 | |
| SCHEMBL10126734 | 0.84 | KMT2A (0.40) | KDRHDAC6AURKALCKMET | |
| SCHEMBL4668018 | 0.83 | CAMKK2 (0.38) | CCNCCDK8KDRAURKAFGFR1 | |
| SCHEMBL4667699 | 0.83 | CAMKK2 (0.38) | CCNCCDK8KDRAURKAFGFR1 | |
| SCHEMBL4669118 | 0.81 | MMP1 (0.53) | GSK3BMAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL4669121 | 0.81 | MMP1 (0.53) | GSK3BMAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL4666025 | 0.80 | HPGD (0.49) | HDAC6GSK3BMEN1ALDH1A1HPGD | |
| SCHEMBL4666020 | 0.80 | HPGD (0.49) | HDAC6GSK3BMEN1ALDH1A1HPGD | |
| SCHEMBL10126737 | 0.79 | CA12 (0.42) | CCNCCDK8AURKAGSK3AGSK3B | |
| SCHEMBL4667782 | 0.78 | SMN1; SMN2 (0.52) | HDAC6GSK3BMEN1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1980561-B1 | Substituted 1h-pyrazolo[3,4-b] pyridine derivatives active as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL (IT) | 2013-10-09 | — | — | EP | claimed |
| EP-1980561-A1 | Substituted 1h-pyrazolo[3,4-b] pyridine derivatives active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2008-10-15 | — | — | EP | claimed |
| EP-1980561-B1 | Substituted 1h-pyrazolo[3,4-b] pyridine derivatives active as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL (IT) | 2013-10-09 | — | — | EP | disclosed |
| EP-1980561-A1 | Substituted 1h-pyrazolo[3,4-b] pyridine derivatives active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2008-10-15 | — | — | EP | disclosed |