Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.52 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | DHFR | P00374 | 1/20 | 0.44 |
| ▸ | MPO | P05164 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5514299 | 0.89 | TSHR (0.44) | KEAP1NFE2L2CYP3A4CYP2D6MAPT | |
| SCHEMBL9800976 | 0.82 | NPC1 (0.50) | MAPTRAB9ATDP1ALDH1A1KDM4E | |
| SCHEMBL225741 | 0.82 | NPC1 (0.50) | MAPTRAB9ATDP1ALDH1A1KDM4E | |
| SCHEMBL20193405 | 0.81 | TSHR (0.39) | KEAP1NFE2L2CYP3A4CYP2D6MAPT | |
| SCHEMBL9840547 | 0.81 | TSHR (0.39) | KEAP1NFE2L2CYP3A4CYP2D6MAPT | |
| SCHEMBL11409022 | 0.80 | NPC1 (0.48) | MAPTRAB9ATDP1ALDH1A1KDM4E | |
| SCHEMBL5609677 | 0.80 | KDM5A (0.40) | KEAP1NFE2L2CYP3A4CYP2D6MAPT | |
| SCHEMBL13893584 | 0.79 | CYP3A4 (0.50) | KEAP1NFE2L2CYP3A4CYP2D6MAPT | |
| SCHEMBL9685869 | 0.79 | TSHR (0.38) | KEAP1NFE2L2CYP3A4CYP2D6MAPT | |
| SCHEMBL13412750 | 0.79 | ALDH1A1 (0.50) | KEAP1NFE2L2CYP3A4CYP2D6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513054-B1 | BICYCLIC DERIVATIVES USEFUL AS INHIBITORS OF DPP-1 | JANSSEN PHARMACEUTICA NV (BE) | 2016-03-09 | — | — | EP | claimed |
| US-6362342-B1 | BIOSYNTHESIS; DRUG LIBRARIES | LION BIOSCIENCE AG (DE) | 2002-03-26 | — | — | US | claimed |
| CN-106380414-B | A kind of mefenamic acid and its synthesis technology | 西安利君精华药业有限责任公司 | 2018-07-03 | — | — | CN | disclosed |
| CN-106380414-A | Mefenamic acid and synthesis technology thereof | 西安利君精华药业有限责任公司 | 2017-02-08 | — | — | CN | disclosed |
| WO-2015021943-A9 | INDUCING NEUROGENESIS BY AXIN ENHANCER | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2015-12-30 | — | — | WO | disclosed |
| WO-2015021943-A1 | INDUCING NEUROGENESIS BY AXIN ENHANCER | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2015-02-19 | — | — | WO | disclosed |
| CN-104231744-A | Ink, ink cartridge, ink jet recording device, ink jet ink printed matter, compound, and composition | RICOH CO LTD | 2014-12-24 | — | — | CN | disclosed |
| US-8455252-B2 | Materials and methods for sensitizing multidrug resistant cells | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORP. (US) | 2013-06-04 | — | — | US | disclosed |
| US-8455252-B2 | Materials and methods for sensitizing multidrug resistant cells | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORP. (US) | 2013-06-04 | — | — | US | disclosed |
| US-20080051419-A1 | AMINE DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER INC. | 2008-02-28 | — | — | US | disclosed |
| WO-2008012635-A2 | AMINE DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER PRODUCTS INC. (US) | 2008-01-31 | — | — | WO | disclosed |
| EP-1189891-A1 | TRIAZOLE COMPOUNDS AND COMBINATORIAL LIBRARIES THEREOF | LION Bioscience AG (DE) | 2002-03-27 | — | — | EP | disclosed |
| US-6362342-B1 | BIOSYNTHESIS; DRUG LIBRARIES | LION BIOSCIENCE AG (DE) | 2002-03-26 | — | — | US | disclosed |
| WO-2001000594-A1 | TRIAZOLE COMPOUNDS AND COMBINATORIAL LIBRARIES THEREOF | LION BIOSCIENCE AG (DE) | 2001-01-04 | — | — | WO | disclosed |
| US-4029609-A | HEAT RESISTANCE | TOYO BOSEKI KABUSHIKI KAISHA (JA) | 1977-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080051419-A1 | AMINE DERIVATIVES USEFUL AS ANTICANCER AGENTS | CCNY, CCND2, CCND1 | KEAP1 904/4885NFE2L2 2520/4885CYP3A4 3729/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.