Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD | O00767 | 4/20 | 0.39 |
| ▸ | MGLL | Q99685 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.33 |
| ▸ | GPR183 | P32249 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4837579 | 0.90 | SCD (0.38) | SCDMGLLPOLBHPGDHSD17B10 | |
| SCHEMBL4780056 | 0.85 | SCD (0.38) | SCDMGLLHPGDLMNATP53 | |
| SCHEMBL4778523 | 0.82 | SCD (0.40) | SCDMGLLLMNATP53ALOX15 | |
| SCHEMBL4775840 | 0.75 | HDAC8 (0.45) | SCDMGLLTSHRHDAC1HDAC6 | |
| SCHEMBL4775889 | 0.73 | SCN5A (0.42) | SCDMGLL | |
| SCHEMBL4778154 | 0.73 | ABL1 (0.34) | LMNAHSD17B10RECQLKMT2AKDM4E | |
| SCHEMBL4772658 | 0.71 | CACNA2D1 (0.39) | SCDCYP2C9 | |
| SCHEMBL4774662 | 0.69 | CACNA1B (0.41) | SCDPOLBHPGDLMNATSHR | |
| SCHEMBL4753765 | 0.68 | HCRTR1 (0.44) | SCDMGLLCYP2C9KDM4E | |
| Hydrochloric Acid SCHEMBL3466376 | 0.67 | HCRTR1 (0.43) | SCDMGLLCYP2C9KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996550-A2 | CARBOXYAMINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF HDAC DEPENDENT DISEASES | Novartis AG (CH) | 2008-12-03 | — | — | EP | disclosed |
| WO-2007038459-A2 | CARBOXYAMINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF HDAC DEPENDENT DISEASES | NOVARTIS AG (CH) | 2007-04-05 | — | — | WO | disclosed |