Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | RBP4 | P02753 | 2/20 | 0.41 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.40 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.40 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.40 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.39 |
| ▸ | SCD | O00767 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4772658 | 0.80 | CACNA2D1 (0.39) | EPHX2CYP2C9CYP2C19CACNA2D1CACNA1B | |
| SCHEMBL4776766 | 0.73 | L3MBTL1 (0.53) | L3MBTL1HTTEPHX2CYP2D6CYP2C9 | |
| SCHEMBL7943306 | 0.71 | L3MBTL1 (1.00) | L3MBTL1HTTEPHX2GAARBP4 | |
| SCHEMBL18705011 | 0.70 | L3MBTL1 (0.76) | L3MBTL1HTTEPHX2DPP4DPP9 | |
| SCHEMBL4753470 | 0.69 | SCD (0.51) | CYP2C9CYP2C19HSD11B1SCD | |
| Hydrochloric Acid SCHEMBL17560373 | 0.68 | L3MBTL1 (0.78) | L3MBTL1HTTEPHX2GAARBP4 | |
| Hydrochloric Acid SCHEMBL3466569 | 0.68 | SCD (0.50) | CYP2C9CYP2C19HSD11B1SCD | |
| SCHEMBL31350899 | 0.68 | L3MBTL1 (0.71) | L3MBTL1HTTCYP2D6GAACACNA2D1 | |
| SCHEMBL7955601 | 0.68 | L3MBTL1 (0.89) | L3MBTL1HTTEPHX2GAASMN1; SMN2 | |
| SCHEMBL1461593 | 0.66 | L3MBTL1 (0.86) | L3MBTL1HTTEPHX2GAARBP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996550-A2 | CARBOXYAMINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF HDAC DEPENDENT DISEASES | Novartis AG (CH) | 2008-12-03 | — | — | EP | disclosed |
| WO-2007038459-A2 | CARBOXYAMINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF HDAC DEPENDENT DISEASES | NOVARTIS AG (CH) | 2007-04-05 | — | — | WO | disclosed |